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Raman spectroscopy has emerged as a rapid and powerful tool for critical applications in forensic science. The advantage of Raman spectroscopy is that the Raman signal is often selective to pharmacologically active drug substances [1, 2]. On the other hand, pharmacologically inactive substances do not exhibit a Raman signal and their spectra are often masked by fluorescence. This could be advantageous in identifying drug substances, especially new psychoactive substances. read more

Innovation focused on addressing unmet medical need and improving outcomes for patients is one of the central and overarching goals of the life sciences sector, with significant contributions from large biopharmaceutical companies, biotech and specialty pharma companies, drug delivery companies, and academia. For decades the creation of new medicines has increased quality and quantity of life for patients around the globe. Just looking at the past decade reveals great progress on various fronts, including a 40% reduction of cardiovascular deaths in the US, a significant increase of life expectancy of HIV patients, and the advent of cancer medicine–diagnostic combinations, among others [1]. Scientific breakthroughs leading to novel and valuable medicines are benefiting both patients and their caregivers, and ultimately, society. read more

Regulatory agencies are increasingly requesting a more comprehensive evaluation of the potential contamination of biopharmaceuticals from leachables both from the container closure system used to store the biopharmaceutical and other possible sources such as the manufacturing system. To meet this demand, Total Organic Carbon (TOC) has been investigated as a possible technique that can be used to assess leachables from biopharmaceutical manufacturing equipment and thus provide data to assess the potential risk that biopharmaceutical manufacturing leachables pose to patient safety and product quality. read more