Limited drug solubility is a problem facing a majority of drugs currently being developed. Poor solubility can lead to low or variable bioavailability of APIs. Hot melt extrusion is a solid dispersion technology that can disperse the API into a polymer matrix through the application of heat and mechanical energy.This study evaluated a pharmaceutical-grade polyvinyl alcohol (PVA) as the matrix polymer for HME application. Therefore, performance characteristics such as API solubility enhancement, high thermal stability, and the stability of amorphous solid dispersions at high dose were analyzed.
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