High-pressure liquid chromatography systems and instruments cover a wide range of chromatography sciences. This range includes; partition chromatography, normal-phase chromatography, displacement chromatography, reversed-phase chromatography, size-exclusion chromatography, ion-exchange chromatography, bioaffinity chromatography and aqueous normal-phase chromatography.
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| Company | Waters Corporation | Waters Corporation | Waters Corporation | Waters Corporation | Waters Corporation |
| Item | Biopharm UNIFI System | ACQUITY UPC2 System | ACQUITY UPLC I-Class System | nanoACQUITY UPLC System with HDX Technology | PATROL UPLC Laboratory Analyzer System |
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| Vendor Product Page | Company Product Page | | Company Product Page | Company Product Page | Company Product Page |
| Detector(s) | Ultra-fast electron multiplier and hybrid ADC detector electronics to provide outstanding sensitivity and quantitative performance | PDA | UPLC-Optimized Optical and Mass Detectors | TUV or TDA Detector | UPLC-Optimized Optical |
| Flow Rate | 0.010 to 2.000 mL/min (in 0.001 mL increments) | 0.010 to 4.000 mL/min (in 0.001-mL increments) | 0.010 to 2.000 mL/min (in 0.001 mL increments) | 200 nL/min to 100 uL/min | 0.010 to 2.000 mL/min, in 0.001-mL increments |
| Max. Pressure | 15,000 psi (up to 1 mL/min) or 9000 psi (up to 2 mL/min) | 6,000 psi (413 bar), up to 4 mL/min | 18,000 psi (up to 1 mL/min) or 12,000 psi (up to 2 mL/min) | 10,000 psi | 15,000 psi up to 1 mL/min, 9000 psi up to 2 mL/min per pump, not more than 15,000 psi total |
| Description | The Waters Biopharmaceutical System Solution with UNIFI integrates robust UPLC/MS characterization technology with comprehensive software. This is an application-focused platform that captures complex and comprehensive mass spectrometry and | UltraPerformance Convergence Chromatography™(UPC2™) is a new category of separations science that makes the complex analysis...routine. This new technology marries the unrealized potential of SFC with Waters proven UPLC® technology | ACQUITY UPLC® I-Class provides the most powerful solution to the most critical need in separation science today – successfully analyzing compounds that are limited in amount or availability amid a complex matrix, more rapidly than ever before. | For higher order structure studies, hydrogen deuterium exchange with mass spectrometry – alternatively referred to as H/D exchange, HDX, or HXMS – has become indispensable for biotech companies. Waters has turned what was a highly manual analytical | The PATROL UPLC® Laboratory Analyzer provides real-time quantitative analysis of chemical reactions in process development and optimization laboratories. Proven UPLC® Technology and Real-TIME LC™ analysis have been integrated to an online |
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