American Pharmaceutical Review: A Russell Publishing Publication

Winter 2003

Articles

• Application of Systems Biology to Drug Discovery

  Shawn T. Estrem, Ph.D.
  Eli Lilly and Company

• Assessing, Understanding and Minimizing Variability of DNA Microarrays

  Andrew Brooks, Ph.D. and Agnes Viale, Ph.D.
  University of Rochester and Memorial Sloan-Kettering Cancer Center

• Fast HPLC-MS/MS Analyses for Small Molecules

  Yunsheng Hsieh, Ph.D., Jean-Marc Brisson, & Ganfeng Wang
  Drug Metabolism and Pharmacokinetics Department, Schering-Plough Research Institute

• Managing Scientific Intelligence from Conception to Product Launch

  Joseph A. Turpin¹ & Douglas Perry, Ph.D.^{2
  1}Lilly Research Laboratories; Eli Lilly and Company, Inc.
  ²Indiana University School of Informatics

• Measuring and Interpreting Particle Size Distribution

  Brian Scarlett
  Particle Engineering Research Center, University of Florida

• Media Fills 101: How to Design, Conduct and Document Media Fills for Aseptic Processes

  Sarah K. Doshna
  Bristol-Myers Squibb

• Meeting the Regulatory Challenges Associated with Process Analytical Technologies

  Jeffrey J. Blumenstein, Ph.D.
  Pfizer Inc.

• Overcoming the Challenges of Noninvasive Protein and Peptide Delivery

  Michael R. DeFelippis, Ph.D.
  Eli Lilly and Company

• Part 11 is Dead - Long Live Part 11

  R.D. McDowall, Ph.D.
  McDowall Consulting

• PAT Applications: Qualification of Equipment and Validation of Analytical Methods

  Carl A. Anderson, Ph.D.
  Duquesne University Center for Pharmaceutical Technology

• Pharmaceutical Inhalation Aerosol Powder Dispersion - an Unbalancing Act

  Anthony J. Hickey, Ph.D.
  School of Pharmacy, University of North Carolina at Chapel Hill

• Practical Aspects of Freeze-Drying of Pharmaceutical and Biological Products Using Non-Aqueous Co-Solvent Systems

  Dirk L. Teagarden, Ph.D.
  Pfizer Global Pharmaceutical Sciences, Department of Sterile Products Development

• Screening Technologies for Ion Channel Targets in Drug Discovery

  Wei Zheng, Ph.D.¹ and Laszlo Kiss, Ph.D.^{2
  1}Department of Automated Biotechnology and ²Department of Molecular Pharmacology, Pennsylvania

• The Exploration and Use of Thermal Analytical Technologies During Formulation and Process Development of Freeze-Dried Products

  Nathaniel Milton, Ph.D., Abira Pyne, Ph.D., Dinesh Mishra, Ph.D., and Lian Yu, Ph.D.
  Eli Lilly and Company

• Total Pattern Analysis Using the New Organic Powder Diffraction File: PDF-4/Organics

  Fangling Needham, Ph.D., and John Faber, Ph.D.
  The International Centre for Diffraction Data (ICDD)