Automating the UF/DF Process with In-Line Concentration Measurement to Reduce Cycling Time and Accelerate Process Development

Previously Aired on November 15th, 2022

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The KrosFlo® KR2i RPM™ System uses in-line variable pathlength technology to accurately measure concentration in the TFF process stream (in-line). Would you like a Repligen analytics technical specialist to contact you to learn more about the KR2i RPM System? *

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Overview

This presentation will introduce an integrated system to automate the TFF process based on concentration measurement acquired via in-line variable pathlength spectroscopy. Real-time concentration measurement enables repeatable results, insensitive to the types of variation commonly seen in mass balance only systems.

Automated process control is demonstrated for various final concentration endpoints, suggesting a better solution for the UF/DF process with key advantages over existing methods.

In this webinar you’ll learn:

Variable pathlength technology (VPT) placed in-line enables real-time concentration measurements as a process progresses, even at high concentrations
TFF automation enables rapid lab-scale testing with minimal manual intervention
The union of VPT and TFF automation enables a repeatable result insensitive to the types of variation commonly seen in mass balance systems

Who should attend:

Process development scientist
Scientist doing UF/DF with mass balance-TFF systems
PAT/Automation Specialists

Presenters

Derek Carroll

(Presenter)
Director of Research & Development
Repligen
View Biography

Mike Auerbach

(Moderator)
Editor-in-Chief,
American Pharmaceutical Review