Proper characterization of particle systems during bioprocess harvest is challenging, leading to issues in capacity and efficiency in other unit operations. Inline particle analysis provides direct, actionable process information that can be used to optimize harvest processes where other techniques such as turbidity are lacking.

In this webinar, we evaluate acidic precipitation of nucleic acids in cell culture broth to improve filtration and pre-chromatography impurity clearance. Alternative methods of HCP clearance and filtration outcomes with different flocculation reagents were also evaluated. In each process, offline analysis and filtration throughput studies alone were insufficient to fully characterize the processes. Inline particle analysis was required to understand clearance mechanisms and optimize harvest.

In this webinar you’ll learn:

• How inline particle system characterization correlates directly to harvest parameters such as filter capacity and impurity clearance
• How inline image analysis can provide insight into the morphology of diverse particle species and process mechanisms that are often impractical to characterize with offline methods
• How inline particle characterization can accelerate process understanding and reduce overall experimental resource demands

• Bioprocess development scientists, engineers, and technicians
• Persons working on harvest operations in bioprocesses
• Principals, managers, and directors supporting bioprocesses