PROPOR TFF, Parker domnick hunter’s new range of hollow fibre tangential flow filters, offers a number of benefits for microfiltration and ultrafiltration applications in the biopharmaceutical industry.
Parker domnick hunter, with lead operations in Birtley, UK, and Oxnard, California, is a leading supplier of automated bioprocessing solutions, which incorporate filtration, bioprocess containers, overmolded manifolds and sensor technology.
The PROPOR TFF range includes single-use, reusable and autoclaveable filters which are designed to increase productivity, maximize yield, achieve reproducible product quality and minimize filtration costs.
The range enhances Parker domnick hunter’s established SciLog® range of automated TFF systems.
Each PROPOR TFF filter features a modified polyethersulphone membrane (mPES) – the most technologically advanced filter membrane material.
The robust, 100% integrity tested mPES membrane delivers extremely low binding characteristics to prevent fouling and maximize throughput, lifetime and yields, while the extremely narrow porosity specifications minimizes bioprocess variability so that product consistency is maintained when scaling up to manufacturing level.
Tangential flow filtration operations are used extensively throughout biopharmaceutical manufacturing processes for both microfiltration and ultrafiltration applications.
PROPOR TFF filters can be used in microfiltration applications such as clarification of cells and cell lysates, and in ultrafiltration applications for the concentration of diafiltration or recombinant proteins, such as monoclonal antibodies.
Their open channel structure minimizes fouling in microfiltration applications with feed streams that contain a high level of particles.
In ultrafiltration applications, PROPOR TFF filters will typically be 4-6 times cheaper than the equivalent membrane area in cassette format.
In either microfiltration or ultrafiltration applications, PROPOR TFF filters scale-up well by increasing the length of the filter or preferably by maintaining the fibre path length and increasing the number of fibres.