Influence of Different Lubricants on Tableting Characteristics and Dissolution Behavior

Lubricants are a very important part of the tablet formulation. During the tableting process, powder particles are forced to rearrange under the increasing compression force. Lubricants influence this rearrangement and bonding process depending on their molecular structure. After compression, the tablet has to be ejected by the lower punch of the tablet press. The lubricant in also important in this step of the process because it inhibits sticking between the tablet and the punch, which can lead to damage and stop the machines. Finally, the lubricant influences the dissolution and disintegration times and, thus, the quality attributes of the tablets. Due to their importance in formulating tablets, there are a lot of lubricants on the market. Most of them are characterized by a long fatty acid chain which imparts hydrophobicity to the lubricant. Examples for such commonly used lubricants are magnesium stearate, sodium stearate, stearic acid, and sodium stearyl fumarate. These lubricants were utilized in this study about the influence of lubricants on tableting characteristics.

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