Pharmaceutical solution calorimetry is particularly useful during the development phase of a solid drug compound, as it allows researchers to perform analysis of crystalline content and verify stability. The change in the heat capacity of the bonds within a molecule can be measured by differential scanning calorimetry and allows researchers to detect points of enthalpy and characterize and map the temperature-specific behavior of a drug product.
Differential scanning calorimetry allows researchers to examine the conformational changes within a biomolecule as it is exposed to a range of temperatures, allowing for a look into the protein stability and folding properties. Pharmaceutical calorimeters allow drug developers to verify the point at which a drug might become crystallized or unstable, which is especially useful in the final development of amorphous drug compounds.