Using Single-Use Technology to Enable Single- Pass TFF
Emily Peterson, Senior BioManufacturing Engineer
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Chapters
Introduction
Agenda
Background – What is Single-Pass TFF?
How does SPTFF work?
Single-Pass Tangential Flow Filtration (SPTFF)
Versatility in bioprocessing
In-process volume reduction
Process intensification
High concentration formulation
Using proven, high performing TFF filters
Agenda cont.
Current trends in the biopharmaceutical industry
Challenges and opportunities in TFF
Next Gen’ Is…
Pellicon® Capsule design benefits
Configurations for Single Pass
Agenda cont..
Pellicon® 3 and Pellicon® Capsule Perfomance Study
Feed flux comparison – 25 g/L section 3
Process Stability Comparison – 25 g/L @ 0.14 LMM
Agenda cont...
SPTFF for post clarification harvest volume reduction
Scale-down Process Conditions Scoping Trial with “mAb02”
Scale Down Study Performance Analysis
Scale-up Trial Results
Improve batch chromatography with SPTFF
Agenda cont....
Summary
Pellicon® single-pass tff is part of...
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© 2019 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada.
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