Integrated Buffer Delivery and Management for Facility Intensification and Cost Reduction
Michael Felo, Director of Downstream Process Integration
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Chapters
Introduction
Market Trends, Business Drivers and Key Enablers to Drive Next Generation BioProcessing:
Next Generation Processing: Evolutionary Journey in mAb Manufacturing
Buffer Preparation Overview
Buffer preparation is an essential function but does not add value
Challenges in Buffer Preparation require new approaches
Significant Desire to Move toward Outsourced Buffer Preparation
Preparation cost Models
3 Buffer Preparation Methods for Cost Models
MAb Facility Considerations for Buffer Preparation Scenarios
18% Reduction in Cleanroom Area Utilizing Buffer Concentrates
Ready to Use Buffers Reduce Costs up to 43% over Made-in-House Buffers
Buffer Concentrates Reduce Costs up to 16% over Made-in-House Buffers
Buffer Concentrates Reduce Labor and CAPEX by ≥50%
Buffer Concentrates Cost Competitive at Consumption Rate of 4 million L/yr
Integrated Delivery & Management
Delivering Certainty in Buffer Preparation and Management in < 16 weeks
BioContinuum™ Buffer Delivery Platform
Liquid production sites
MilliporeSigma Sterile Liquid Capabilities at a glance
BPOG Buffer Workstream defined Design Space for Configurable Concentrates
Volumetric flow control delivers accuracy and precision for consistent buffer preparation
Accuracy and Precision delivered with MilliporeSigma /YMC dilution system
Configurable Assemblies Provide Flexibility and Delivery in 8 weeks
Summary
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