Ashland and Oakwood Laboratories will showcase application of Viatel™ bioresorbable polymers and customized chemistry in long-acting injectable (LAI) microsphere formulations from the Chroniject™ platform exploring:

• An overview of the LAI field
• Relevant polymer selection per API and target release profiles
• Microsphere manufacturing technologies and problem solving
• Tuning drug release and profiles for weeks to several months
• Customized chemistry options to solve stability challenges
• Successful scale-up and manufacture of robust microspheres

Ashland will show how chemistry can be coupled with formulation knowledge for in-situ forming depots, microspheres/nanoparticles, and pre-formed solid implants. Viatel™ customized chemistry and its versatility to solve formulation challenges will be discussed.

Oakwood Labs will showcase their Chroniject™ microsphere technology platform, specifically the effect of polymer selection and process parameters for optimizing drug load, release duration, particle size, and encapsulation efficiency. These results will be based on (1) a small molecule, and (2) a peptide with varied release needs.

Chroniject™ allows for release durations ranging from weeks to one year, using a process that is reproducible, scalable, and able to achieve consistent critical quality attributes under cGMP for multiple therapeutic indications.