BIOne Single-use Bioreactor System from Distek, Inc.

Description

The BIOne benchtop scale single-use bioreactor (SUB) is for mammalian cell growth, cell therapy, insect cells, and other unique applications performed in a stirred tank bioreactor. The gamma irradiated BIOne SUB is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a disposable SUB within a matter of seconds. Upon media addition, the liner expands and molds to the glass vessel, preserving the geometry of the existing bioreactor.

The BIOne SUB’s liner material emulates the large-scale SUBs used in pilot and commercial biopharma production facilities around the world. Performing R & D studies using the most similar material on the market streamlines your tech transfer and can de-risk your process BEFORE transferring to pilot scale.

  • Customizable above & below the Headplate -
    • 2L & 5L Working Volume
    • Optional Single-Use pH Probe
    • Increased Throughput
    • Weldable Tubing
    • Flute, Micro & Open Pipe Sparging Options
    • Non-Invasive DO & Optional pH Probe Ports
    • USP Class VI Materials
    • Repligen® ATF Perfusion Tube Compatible
    • Animal Derivative-Free
    • Low Antioxidant Liner Material
    • Compatible with Most Manufacturers’ Glass Vessels and Controllers
  • DO & pH Probe Ports -
    • Non-Invasive (Amperometric DO/Optical pH)
    • PG-13.5 (Optical DO/Electrochemical pH)
    • Optional Integrated Single-Use pH Probe
  • Pitched Blade Impeller - Single or Dual Impeller
  • Sparging Options -
    • Flute Sparger (7 x 1.5 mm hole)
    • Micro Sparger (20-40 µm pore size)
    • Open Pipe Sparger (1 x 3.0 mm)
  • Low Antioxidant Liner Material -
    • Outer Layer (LDPE) – Mechanical Strength
    • Middle Barrier Layer (EVOH) – Gas Barrier
    • Contact Layer (ULDPE) – Cell Culture Compatible, Biologically Inert