How to Increase the Solubility and Bioavailable with Hot Melt Extrusion?

Hot Melt Extrusion (HME) is an enabling processing technology that dates back many decades in the plastics, food, and other industries, and has been applied in pharmaceuticals for nearly 30 years now. Pharmaceutical manufacturers choose HME to enable poorly soluble compounds. When executed properly, HME advances poorly soluble compounds in the development pipeline, without adding delays, cost, or significant post-processing activities, and can scale to commercial manufacturing.

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