Detection of Pyrogens Pyromat 2019008029

A pyrogen is, by definition, a substance that produces a rise in temperature in a human or animal. Pyrogens constitute a heterogeneous group of contaminants comprising microbial and non-microbial substances. The most widely known pyrogen is the endotoxin (LPS = Lipopolysaccharide), which is produced by Gram-negative bacteria. Other microbial substances include those derived from Gram-positive bacteria such as lipoteichoic acid (LTA) or, particles from viruses and pyrogens originating from yeasts and fungi. Non-microbial pyrogenic substances can be rubber particles, microscopic plastic particles or metal compounds in elastomers.

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