UCLA and Royalty Pharma have announced that UCLA has sold its royalty interest connected with a leading prostate cancer medication, Xtandi, whose development was based on discoveries by campus researchers.
Royalty Pharma has acquired rights to a portion of the future Xtandi royalties co-owned by UCLA, researchers working at the university at the time of the discoveries and a research organization. The transaction includes a cash payment of $1.14 billion and potential additional payments based on future Xtandi sales.
UCLA will use its share of the proceeds — approximately $520 million — to support research programs aimed at generating additional discoveries that lead to medications and other products that serve the public good. UCLA also will support undergraduate scholarships and graduate student fellowships, a campus priority.
"Xtandi is the result of a unique collaboration between researchers from various academic units across campus and an outstanding example of basic science leading to a therapy that is bringing extraordinary benefits to prostate cancer patients worldwide," said UCLA Chancellor Gene Block. "By selling future royalty rights to Royalty Pharma, we are strategically supporting one of our essential missions — funding and generating research with practical applications that serve the public good. Facilitating equal access to education also is a campus priority, and we will use a portion of the sale proceeds to support scholarships and fellowships."
"We have great admiration for UCLA's scientists and physicians," said Royalty Pharma founder and CEO Pablo Legorreta. "Through their discovery of Xtandi, they have improved the lives of hundreds of thousands of prostate cancer patients who suffer from this deadly disease. Royalty Pharma's mission is to make the life sciences research and development ecosystem more efficient and productive, and to accelerate research through innovative transactions such as this one."
By selling the royalty interest and prudently investing proceeds, UCLA seeks to provide stability and minimize risk associated with the volatility of the pharmaceutical industry marketplace.
UCLA will hold its share of the proceeds in a broadly diversified portfolio managed by the University of California's office of the chief investment officer. Based on the pool's average annual returns, UCLA anticipates it will receive approximately $60 million annually until 2027.
Campus officials said they anticipated proceeds of the sale will contribute a small percent incrementally to UCLA's total budget.
"Given ongoing funding pressures, we are pleased to have these much-needed additional resources to invest in programs that directly serve the public by fostering research that leads to commercially viable products and by educating students," said Steve Olsen, UCLA's vice chancellor and chief financial officer.
Xtandi is based on a chemical compound that was developed at UCLA. The oral medication inhibits the androgen receptor, the engine of prostate cancer progression. Where other treatments have failed, Xtandi has extended the lives of men with metastatic castration-resistant prostate cancer. In one phase 3 clinical study of patients previously treated with chemotherapy, Xtandi reduced the risk of death by 37 percent and increased median survival by 4.8 months, compared to those who took a placebo. In a separate phase 3 clinical study of patients not previously treated with chemotherapy, Xtandi reduced the risk of death by 23 percent and increased median survival by four months.
The research that began in the early 2000s and culminated in the creation of Xtandi was conducted by teams led by Michael Jung, aUCLA distinguished professor of chemistry and biochemistry, and Dr. Charles Sawyers, a former UCLA professor of medicine, urology and pharmacology and researcher at UCLA's Jonsson Comprehensive Cancer Center who now is at Memorial Sloan Kettering Cancer Center in New York.
Sawyers, who was an investigator of the Howard Hughes Medical Institute while at UCLA, initially identified the fundamental basis that underlies why prostate cancer fails to respond to first-generation anti-cancer drugs. This provided a new paradigm to discover next-generation therapies for the treatment of late-stage prostate cancer. He and his research colleagues set up a collaboration with Jung, a member of both the cancer center and the California NanoSystems Institute at UCLA who, along with his team, designed and synthesized Xtandi. Xtandi's discovery demonstrated that this second-generation anti-androgen functioned as an effective and safe anti-cancer therapy in preclinical models of early- and, importantly, late-stage prostate cancer.
In 2005, UCLA licensed the chemical compound's patent to pharmaceutical company Medivation Inc. of San Francisco. Medivation received FDA approval in 2012 to market Xtandi as a prostate cancer medication. Medivation and its sub-licensee, Astellas Pharma Inc. of Tokyo, are now selling Xtandi worldwide. UCLA has no role in the marketing or sale of Xtandi.
By virtue of patent and licensing agreements administered by UCLA, the campus, the researchers and Howard Hughes Medical Institute shared a royalty interest in worldwide net sales of Xtandi. UCLA owns 43.875 percent of the royalty interest.
The American Cancer Society estimates that 180,890 new cases of prostate cancer will be diagnosed in 2016, and that 26,120 men will die from the disease in 2016. About 1 in 7 men is likely to be diagnosed with prostate cancer, according to the American Cancer Society.
UCLA is a national leader in converting research discoveries into practical applications. The UCLA Office of Intellectual Property and Industry Sponsored Research manages nearly 3,000 active inventions and more than 1,000 U.S. patents.