Pique Therapeutics announced positive results for PT 107 from its Phase 2 clinical trial in patients with late-stage, second-line non-small cell lung cancer (NSCLC).
Median overall survival for patients receiving treatment with PT 107 (PT 107 arm) was 12.5 months versus 8.4 months for patients who received placebo (control arm), with a hazard ratio of 0.65 (p=0.06, all p-values two-sided). In the subset of 71 non-squamous patients, median overall survival was 15.5 months (PT 107 arm) vs. 5.8 months (control arm), with a hazard ratio of 0.46 (p<0.01).
"We are very encouraged to see such positive results with a single agent in late stage non-small cell lung cancer," said Christopher S. Meldrum, President of Pique Therapeutics. "The improvement in overall survival, particularly the significant 10-month benefit seen in non-squamous patients, highlight the promise of PT 107."