AUM Biosciences, a global clinical-stage biotech company focused on discovering and developing novel targeted oncology therapies, has entered into a clinical trial collaboration and supply agreement with Roche to evaluate AUM001, the Company’s novel, highly selective MNK1/2 inhibitor, in combination with atezolizumab (Tecentriq®), Roche’s anti-PD-L1 therapy, across multiple solid tumor indications, leading with Non-Small Cell Lung Cancer (NSCLC) and Urothelial Cancer (UC).
“This partnership represents a very important milestone as we expand into new indications for the clinical development of AUM001 and realize the full potential of AUM001. This is part of our commitment to conduct a broad clinical development program to evaluate AUM001 to address unmet medical needs in various solid tumor indications,” said Vishal Doshi, CEO of AUM Biosciences.
As a monotherapy, AUM001 demonstrated excellent safety, tolerability, and target engagement in two Phase 1 studies. In a multiple ascending dose Phase 1 trial completed in March 2021, there were no Grade 3/4 treatment emergent AEs or dose limiting toxicities (DLTs).
“Targeted immunotherapies have improved overall survival in a segment of patients with advanced or metastatic cancers. However, there remains a critical need for novel clinical therapies that can further prolong survival in checkpoint inhibitor responsive patients as well as make unresponsive patients responsive AUM001 has a unique proposition where we anticipate preventing or delaying T-cell exhaustion as well as potently stimulating the innate immune system will lead to superior outcomes for cancer patients,” noted Harish Dave, MB, ChB, MBA, CMO of AUM Biosciences.
Tecentriq® (atezolizumab) is a registered trademark of Genentech, a member of the Roche Group.
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