Legend Biotech Corporation announced late-breaking three-year follow-up data from the Phase 3 CARTITUDE-4 study that shows a single infusion of CARVYKTI® (ciltacabtagene autoleucel) significantly extended overall survival (OS) in patients with relapsed or lenalidomide-refractory multiple myeloma who have received at least one prior line of therapy, including a proteasome inhibitor (PI), and an immunomodulatory agent (IMiD), reducing the risk of death by 45 percent versus standard therapies of pomalidomide, bortezomib and dexamethasone (PVd) or daratumumab, pomalidomide and dexamethasone (DPd). CARVYKTI® is now the first and only cell therapy to improve OS versus standard therapies for patients with lenalidomide-refractory multiple myeloma as early as second line. These results were presented as a late-breaking oral presentation at the 2024 International Myeloma Society (IMS) Annual Meeting (Abstract #OA-65) in Rio de Janeiro, Brazil.
“These long-term results are groundbreaking and demonstrate that CARVYKTI significantly extends patients’ overall survival and meaningly improves their quality of life,” said Maria-Victoria Mateos, M.D., Ph.D., Consultant Physician in the Hematology Department and Associate Professor of Medicine at the University of Salamanca, Spain. “These data show that with a single infusion, we can reduce the risk of death and offer multiple myeloma patients the opportunity to live longer.”
“These data underscore Legend’s commitment to providing patients with effective treatments that have the potential to improve their quality of life and prolong survival,” said Ying Huang, Ph.D., Chief Executive Officer of Legend Biotech. “We will continue to investigate the benefits CAR-T can bring to patients by investing significantly in R&D and exploring the full spectrum of CAR-T technologies.”
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