Christoph Saal studied chemistry at the Technical University of Darmstadt with a Ph.D. in Physical Chemistry. Currently he holds a position as Group Leader Molecule Characterization at Merck KGaA. Christoph is a member of EDQM expert groups for spectroscopic methods and holds a teaching position in Pharmaceutical Technology at the Goethe University Frankfurt. Readers may contact the author directly at: christoph.saal@merck.de

Christoph Saal, Ph.D.

Solubility in Pharmaceutical R&D: Predictions and Reality
Thursday, February 20, 2014
Lipinski’s seminal paper on experimental and computational (in silico) methods to estimate the solubility and permeability of drug candidates was published just over 15-years ago. read more
Gaining Knowledge on Drug Absorption: Gathering Physicochemical Data for PK Simulations
Monday, August 27, 2012
Understanding the biopharmaceutical properties of drug substances has become crucial for different phases of pharmaceutical research and development. One of the major goals during research phases such as lead optimization is ... read more
Optimizing the Solubility of Research Compounds: How to Avoid Going Off Track
Saturday, May 01, 2010
Over recent decades, solubility has become one of the key parameters in pharmaceutical research and development as it represents a key prerequisite for ensuring adequate bioavailability of a compound [1, 2, 3, 4]. read more
Pharmaceutical Salts Optimization of Solubility or Even More?
Monday, March 01, 2010
Within the pharmaceutical research and development field, the selection of a suitable solid-state form represents a crucial step. Selecting a solid-state form comprises several decisions, mainly the selection of a salt form ... read more