Polyvinyl Alcohol in Hot Melt Extrusion to Improve the Solubility of Drugs

Limited drug solubility is a problem facing a majority of drugs currently being developed. Poor solubility can lead to low or variable bioavailability of APIs. Hot melt extrusion is a solid dispersion technology that can disperse the API into a polymer matrix through the application of heat and mechanical energy.
This study evaluated a pharmaceutical-grade polyvinyl alcohol (PVA) as the matrix polymer for HME application. Therefore, performance charac­teristics such as API solubility enhancement, high thermal stability, and the stability of amorphous solid dispersions at high dose were analyzed.

Download the Document

    * denotes a required field

    Please fill out the information below. If you are already registered, and this information will be filled out for you.

  • Please enter your first and last name.

  • Please enter the name of the company or institution you work at.

  • Please enter your mailing address.

  • Please enter the e-mail address you would like to be contacted at.

  • Please enter the phone number you would like to be contacted at.

    • By submitting this form, you consent to American Pharmaceutical Review storing your email address and contact information and transmitting your contact information to the content sponsor. You may request to be removed at any time.
  • <<
  • >>