Fluid Bed Granulation and Melt Granulation in Pharmaceutical Manufacturing

Granulation has been employed within the pharmaceutical industry for decades. An essential manufacturing process which is used to form aggregated granules from a powder, it enhances the properties of a drug through material densification and is widely used as an intermediate process within solid dosage manufacturing.

Typically performed once powders containing the active pharmaceutical ingredient (API) and any excipients have been mixed together to a defined ratio, granulation affords many advantages. By modifying the uniformity of API distribution, it decreases segregation of ingredients to generate a consistent product. It can also improve compressibility and flow properties of powders while reducing dust to minimize losses and handling hazards.

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