Lubricant Excipients

Lubricant Excipients

Compression lubricants prevent adherence of granule/powder to punch die/faces and promote smooth ejection from the die after compaction. Lubricants can also be used when compression isn’t involved such as in powder blends for filling into capsules to prevent adherence of granule/powder to equipment surfaces and dosator mechanisms and coating the surface of multi-particulate dosage forms to inhibit agglomeration of individual particles. Minerals such as talc or silica, and fats, e.g. vegetable stearin, magnesium stearate or stearic acid are the most frequently used lubricants in tablets or hard gelatin capsules. The most widely used lubricants in use today are hydrophobic lubricants. These are usually effective at relatively low concentrations and many also have both anti-adherent and glidant properties.

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