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Evidence-based decision making in medicine, education, law enforcement, economics, public policy, etc. have frequently shown that current practices may be plain wrong, not cost effective, or even ...
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Oral bioavailability denotes the fraction of a drug taken orally that arrives in the systemic circulation as an unaltered, active form, and is capable of providing its therapeutic benefit. It is ...
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How is it possible that multiple generations of aseptic manufacturing are simultaneously cGMP? The simple answer is they cannot be. For any technology there is at any point in time where a pinnacle of...
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Drug molecules are becoming more complex. As pipelines continue to be dominated by poorly soluble compounds, the dynamic of solubility and absorption will remain central to development success.
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The recent revisions to the United States Pharmacopeia (USP) General Chapters 41 and 1251 represent one of the most significant updates to pharmaceutical weighing requirements in recent years.
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Isolation technology has significantly improved our ability to manufacture sterile drug products aseptically. Its performance far exceeds that of other aseptic technologies and has been successfully ...
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The “holy grail” of patient-centricity is the transition from injectables to oral dosages, a move that drastically patient compliance and quality of life.
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In biopharmaceutical development, product quality is the highest priority. The resulting structure must be exactly as designed and of exceptional purity.
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Many early adopters of rapid methods later went back to traditional methods. What were these technologies and when did early adopters continue using them?
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When properly integrated through appropriate design planning, validation and alignment with regulatory expectations, continuous monitoring can strengthen contamination control strategies and support ...
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