For pharmaceutical purposes, solubility testing measures the solubility of solid drug compounds in liquid immersions. Solubility testing must be performed under strict laboratory conditions, and the method used to analyze the solubility must be reproducible and documented. Pharmaceutical solubility testing equipment streamlines popular solubility testing protocols, such as the shake flask method or semi-automated potentiometric titrations, on a larger, more reliable scale. Capable of detecting nanograms or milligrams of substance in water or simulated intestinal fluid, pharmaceutical solubility testing equipment allows for cost effective, repeated, and easy-to-record measurements of drug substance solubility. Purchasing considerations include the solubility testing method desired (e.g., solubility measurements per Bjerrum analysis), existing liquid-handling equipment, bench space, operator training, and the need to measure drug solubility in specific conditions, such as in the presence of certain excipients.
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| Company | Pion Inc. | Pion Inc. | Pion Inc. | Pion Inc. |
| Item | µSOL Evolution/EVO 96 High Throughput Miniaturized Shake Flask Solubility | µDISS Profiler Small Volume Dissolution and Solubility Apparatus | µSOL Explorer Miniaturized Shake Flask Solubility | Gemini Profiler Ionization and Lipophilicity Analyzer |
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| Vendor Product Page | Company Product Page | Company Product Page | Company Product Page | Company Product Page |
| Description | A 96 well format test using neat API or DMSO stock solutions with the automated Evolution liquid handling platform.
A complete, turnkey solution that will have you confidently measuring solubility vs. pH, in biorelevant media, in the presence of | Versatile in situ UV measurements for evaluation of various effects on solubility, dissolution, supersaturation and precipitation profiles.
The µDISS Profile™ is a versatile instrument for measuring concentration in real time with fiber optic | A 96 well format test using neat API or DMSO stock solutions with the manual Explorer liquid handling platform.
A complete, turnkey solution that will have you confidently measuring solubility vs. pH, in biorelevant media, in the presence of | An acid base semi-automated potentiometric titrator for pKa, log P, solubility measurements based on Bjerrum analysis.
Determine ionization constants (pKa) and lipophilicity (log P, D) using only submilligrams of API, even on compounds with low |
| Type | Automated/ 96 Well Format | Miniaturized in-situ Concentration Measurements | Manual/ 96 Well Format | Semi-automated |
| Application | Drug Discovery, Early Development | Inquire | Drug Discovery, Early Development | Drug Discovery, Early Development |
| Measuring Range | Inquire | 200 to 720 nm | Inquire | Inquire |
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