Dissolution testers are used to test drug release behavior by simulating capsule or tablet release in vitro. While traditional dissolution testers relied on a water bath to maintain target temperatures, more modern instruments offer bathless dissolution testing while still maintaining the vessel environment. Utilized across formulation development, QA/QC testing, and compliance testing, dissolution testers assist pharmaceutical labs with automating dissolution analysis. When considering various dissolution apparatuses, be sure to consider the reagents to be used as certain models offer increased chemical resistance through more robust paddle materials. Additionally, dissolution instruments which offer automated sampling can assist with analysis which could last hours or days depending on the assay by avoiding the need for manual vessel sampling.
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| Company | Distek, Inc. | Distek, Inc. | Distek, Inc. |
| Item | Model 2500 RTD Water Bath Dissolution Instrument | Eclipse 5300 Automated Dissolution Sampler | Model 2500 Water Bath Dissolution System |
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| Vendor Product Page | Company Product Page | | Company Product Page |
| Dosage Form | Tablets and capsules | Tablets and capsules | Tablets and capsules |
| Speed | 25 to 300 rpm | Inquire | 30 to 300 rpm |
| Number of Vessels | Six Vessels Standard (7 or 8 Optional) | 96 Samples (8 x 12) 16 x 100 mm Test Tubes | Inquire |
| Type | Manual, Automatic | Automatic | Manual, Automatic |
| Temperature Range | Ambient to 55 °C | Inquire | Ambient to 55 °C |
| Sample Volume | 25 - 1000 mL (Volumes below 500 mL Require Low Volume Kit) | Inquire | 25 - 2000 mL (Volumes below 300 mL Require Low Volume Kit) |
| Description | The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a | The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway with a minimal 4.5 mL internal volume increases | Offering maximum flexibility and configurability, the Distek Model 2500 Dissolution System succeeds four generations of the user-friendly 2100 series. A brilliant touch screen and unparalleled command of the instrument with electronic manual, |
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