Dissolution testers are used to test drug release behavior by simulating capsule or tablet release in vitro. While traditional dissolution testers relied on a water bath to maintain target temperatures, more modern instruments offer bathless dissolution testing while still maintaining the vessel environment. Utilized across formulation development, QA/QC testing, and compliance testing, dissolution testers assist pharmaceutical labs with automating dissolution analysis. When considering various dissolution apparatuses, be sure to consider the reagents to be used as certain models offer increased chemical resistance through more robust paddle materials. Additionally, dissolution instruments which offer automated sampling can assist with analysis which could last hours or days depending on the assay by avoiding the need for manual vessel sampling.
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| Company | Distek, Inc. | Distek, Inc. | Distek, Inc. | Distek, Inc. |
| Item | Model 2500 Select Bathless Dissolution Instrument | Model 2500 Water Bath Dissolution System | Opt-Diss 410 UV Fiber Optic Dissolution System | sensIR 3200 Bathless Tablet Disintegration Tester |
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| Vendor Product Page | Company Product Page | Company Product Page | Company Product Page | Company Product Page |
| Dosage Form | Tablets and capsules | Tablets and capsules | Tablets and capsules | Tablets and capsules |
| Speed | 25 to 300 rpm | 30 to 300 rpm | Inquire | < 8 min |
| Number of Vessels | Six Vessels Standard (7 or 8 Optional) | Inquire | Inquire | 2, 4, or 6 |
| Type | Manual, Automatic | Manual, Automatic | Fiber Optic, In-Situ | Manual, Automatic |
| Temperature Range | Ambient to 99 °C | Ambient to 55 °C | Inquire | 20°C to 65°C |
| Sample Volume | 500 - 1000 mL Programmable | 25 - 2000 mL (Volumes below 300 mL Require Low Volume Kit) | Inquire | Up to 1000 mL |
| Description | The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. The system offers great flexibility and | Offering maximum flexibility and configurability, the Distek Model 2500 Dissolution System succeeds four generations of the user-friendly 2100 series. A brilliant touch screen and unparalleled command of the instrument with electronic manual, | No more sampling! The Distek Opt-Diss 410 in-situ fiber optic UV system measures directly in the vessel, eliminating the need for conventional sampling, and with-it consumables like filters, tubing, and syringes, saving time, labor, and money. Moving | The Distek sensIR 3200 combines two exclusive technologies – bathless heating and Near IR sensing to offer the most innovative disintegration tester. Bathless heating not only reduces warm-up times but eliminates the inconveniences associated with |
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