Infrared spectroscopy is a versatile method for determination of fingerprinting and identification of pharmaceutical compounds and functional groups within molecules. It measures energy absorption across the infrared frequency range. Gas, liquid, or solid pharmaceutical samples can be analyzed by infrared spectroscopy.
The Fourier transform infrared (FTIR) spectroscopic method, by which an interferometer is used in place of a monochromator, allows for simultaneous analysis across the infrared frequency range. Due in part to its speed and sensitivity, FTIR has become the standard of pharmaceutical infrared spectroscopy analysis. Pharmaceutical applications of using FTIR instrumentation include the evaluation of raw material and final product analyses prior to inspection and market release.
Purchasing considerations for pharmaceutical infrared spectroscopy equipment include the chemical state of samples to be evaluated, laboratory size, desired instrument portability, laboratory budget, and production regulation, such as meeting process analytical technology (PAT) requirements.