Pharmaceutical Liquid Chromatography Mass Spectrometer (LC/MS Instrumentation)

Liquid chromatography/mass spectroscopy (LC/MS) is a versatile analytical method commonly employed during all phases of pharmaceutical drug development because of its regarded speed, sensitivity, and selectivity. It is commonly used during final analyses of the drug approval process. LC/MS identifies proteins, detects metabolites, determines the molecular weight of drugs, verifies molecular structures and detects for impurities and degradants. Purchasing considerations for pharmaceutical LC/MS systems include the desired ionization method, instrument size, ease of use and operation, and the laboratory budget.

CompanyThermo Fisher ScientificThermo Fisher ScientificThermo Fisher ScientificThermo Fisher Scientific
ItemLTQ FT Ultra Mass SpectrometerQ Exactive benchtop LC-MS/MS Mass SpectrometerTSQ Quantum Ultra Triple Stage Quadrupole Mass SpectrometerTSQ Vantage Triple Stage Quadrupole Mass Spectrometer
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DescriptionThe Thermo Scientific LTQ FT Ultra mass spectrometer is the next generation hybrid FT-ICR featuring a novel ICR cell design, the Ultra Cell. This cell design produces enhanced sensitivity and greater dynamic range. The linear excitation Identify, quantify and confirm with unmatched confidence using the Thermo Scientific Q Exactive mass spectrometer. This benchtop LC-MS/MS combines high-performance quadrupole precursor selection with high-resolution, accurate-mass (HR/AM) Orbitrap Thermo Scientific* TSQ Quantum Ultra mass spectrometer provides ultimate productivity for bioanalytical analysis. Faster method development at the highest possible specificity is routinely achievable with the TSQ Quantum Ultra mass spectrometer. Thermo Scientific* TSQ Vantage triple stage quadrupole mass spectrometer delivers the highest sensitivity with the lowest noise for the quantitative analysis of small molecules, peptides, biosimilars, and biologics. More signal and less noise
TypeIon Trap and Fourier Transform Ion Cyclotron ResonanceBenchtop LC-MSTriple Stage Quadrupole Mass SpectrometerTriple Stage Quadrupole Mass Spectrometer
Pharmaceutical ApplicationInquireScreening and Quantifying Antibiotics, Pesticides or HormonesInquireInquire
Sample StateInquireInquireInquireInquire
Resolution100,000 or 750,000140000InquireInquire
Ionization Method(s)API, APCI, APPI, ESI, Nanospray,S-lens Ion SourceHESI-II heated Electrospray Ionization probeHeated Electrospray (HESI-II)
Mass Range50 to 4000Da0.4 Da to full mass range3000 DaInquire
Scanning SpeedInquireup to 12 HzInquireInquire
Regulatory ComplianceInquireInquire21 CFR Part 11 compliance21 CFR Part 11 compliance
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