Raman spectroscopy is a spectroscopic method utilized by pharmaceutical researchers and developers. Raman spectroscopy offers several advantages for microscopic analysis. Since it is a light scattering technique, specimens don’t need to be fixed or sectioned. Additionally, Raman spectra can be collected from a very small volume; these spectra allow the identification of species present in that volume. Water does not generally interfere with Raman spectral analysis. Thus, Raman spectroscopy is suitable for the microscopic examination of materials, cells, proteins and other biologic compounds.
In Raman imaging, the whole field of view is examined for light scattering integrated over a small range of wavenumbers or Raman shifts. Monochromatic light, e.g., a laser beam, is beamed into a sample and the substance is then analyzed for resulting molecular deformations. These molecular deformations occur in the electric field around a molecule and are referred to as inelastic scattering. Inelastic scattering is an identifying component of the Raman effect. Raman spectroscopy is versatile and can be used to analyze compounds in solid, liquid, and gaseous states.
Articles
- eBook: Raman Imaging in Pharmaceutical Research
- Raman Spectroscopy Streamlines Process Monitoring in Biopharmaceutical Manufacturing
- Accelerating Real-Time Release Testing of Biologics Using Raman Spectroscopy
- NIR and Raman Spectroscopic Experiments to Train the Next Generation of PAT Scientists
- An Interview With... Tom Tague, PhD, Applications Manager, FTIR/Raman Products, Bruker Corporation
- Agilent Technologies Acquires Cobalt Light Systems
- Progress Towards Advanced Pharmaceutical Manufacturing
- 14th Confocal Raman Imaging Symposium in Ulm, Germany
- Pharmaceutical Instrumentation
- Dual-Wavelength Raman Spectroscopy: Improved Compactness and Spectral Resolution
- An Interview with... Dr. Katherine A. Bakeev, Director, B&W Tek
- Transmission Raman Spectroscopy for Pharmaceutical Analysis
- Good Things Come in Small Packages: Hand-Held Raman Instruments Come of Age
- Quantitative Analysis of Injectable Drug Products Using Non-invasive Wideband Raman Technology
- Fast Non-Destructive Detection of Low Level Crystalline Forms in Amorphous Spray Dried Dispersion Using Transmission Raman Spectroscopy and Comparison to Solid-State NMR Spectroscopy
- Raman Spectral Fingerprinting For Biologics Counterfeit Drug Detection
- Evaluating Handheld Spectroscopic Techniques For Identifying Counterfeit Branded And Generic Medicines Worldwide
- Enantioselective Raman Spectroscopy – A new tool for process monitoring in the pharmaceutical industry?
- Identification of Individual Components from the Manufacturing Chain of a Final Vaccine Product by Raman Spectroscopy
- Bruker launches new BRAVO Handheld Raman Spectrometer for Raw Materials identification
- Cobalt Light Systems Launches New US Company
- An Application of Rapid Detection Technologies in a National Regulatory Laboratory Setting: Differentiating Imported and Domestic Drug Products of Oxcarbazepine Using Handheld Raman, Near Infrared, and Portable FTIR Analyzers
- Analysis of Counterfeit FDA-Regulated Products at the Forensic Chemistry Center: Rapid Visual and Chemical Screening Procedures Inside and Outside of the Laboratory
- Renishaw and Bruker team up for a workshop on TERS and co-localised AFM Raman
- Combined LIBS and Raman Spectroscopy: A Versatile Analytical Tool for Pharmaceutical Analysis
- From Detection to Imaging: UV Spectroscopy for Dissolution in Pharmaceutical Development
- Optimizing the Method for Authenticating Pharmaceutical Products of Different Dosage Forms Using Dual Laser Handheld Raman Spectroscopy
- The Evaluation of Dual Laser Handheld Raman Spectroscopy for Identifying Novel Psychoactive Substances
- Raman: Coming of Age for Pharma Applications
- Doing the Splits: Acquisition of High-Resolution Raman Spectra Using Broadband Light Sources
- Advances in 3D Raman Imaging: Tablet Microstructure
- Multivariate Raw Material Trending via Raman Spectroscopy
- Optical Spectroscopic Analysis of Pharmaceutical Co-Crystals
- Automated Raman Chemometric Model Building
- Metrohm to Sell B&W Tech Mobile Spectroscopy Solutions
- Application of Surface-Enhanced Raman Chemical Imaging (SER-CI) to Quantification in Pharmaceutical Tablets
- Automated Morphological Imaging: Deeper Insight into your Pharmaceutical Formulation or Product
- Identifying Collapse in Freeze-Dried Products Via NIR Spectroscopy
- Raman Process Modelling and Glucose Control for Biologics
- Advanced Manufacturing and Process Analytical Technology–for Competitiveness and Resilience in Pharmaceutical Manufacturing
- Detection of Compounds Found in an Unapproved Dermal Filler Using Fourier transform Infrared (FT-IR) and Surface Enhanced Raman Scattering (SERS) Spectroscopy
- An Interview with... Dr. Olaf Hollricher, Co-founder and Managing Director of Research and Development, WITec GmbH
- MilliporeSigma Acquires Resolution Spectra Systems
- eBook: The Benefits of Employing FTIR, RAMAN and NIR Spectroscopy in Your Lab
- In-Line Real-Time Monitoring of CHO Cell Culture Process Parameters Using Raman Spectroscopy