Pharmaceutical Raman Spectroscopy

Raman spectroscopy is a spectroscopic method utilized by pharmaceutical researchers and developers. Raman spectroscopy offers several advantages for microscopic analysis. Since it is a light scattering technique, specimens don’t need to be fixed or sectioned. Additionally, Raman spectra can be collected from a very small volume; these spectra allow the identification of species present in that volume. Water does not generally interfere with Raman spectral analysis. Thus, Raman spectroscopy is suitable for the microscopic examination of materials, cells, proteins and other biologic compounds.

In Raman imaging, the whole field of view is examined for light scattering integrated over a small range of wavenumbers or Raman shifts. Monochromatic light, e.g., a laser beam, is beamed into a sample and the substance is then analyzed for resulting molecular deformations. These molecular deformations occur in the electric field around a molecule and are referred to as inelastic scattering. Inelastic scattering is an identifying component of the Raman effect. Raman spectroscopy is versatile and can be used to analyze compounds in solid, liquid, and gaseous states.
CompanyEnwave Optronics, Inc.Enwave Optronics, Inc.Enwave Optronics, Inc.Enwave Optronics, Inc.Enwave Optronics, Inc.
ItemEZRaman-H Handheld Raman AnalyzerEZRaman-I Series High Sensitivity Portable Raman AnalyzersEZRaman-N Series Raman AnalyzersLabRaman Series Raman Analyzer SystemsProRaman-L Series High Performance Laboratory Raman Analyzer Systems
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DescriptionEnwave's EZRaman-H is a handheld Raman analyzer with desktop instrument performance. They are ideal for Pharmaceutical raw material verification, police and security, Hazmat, etc. The analyzer provides high performance and quality at a very The EZRaman-I Series Raman instruments are designed with great performance, portability, and convenience in mind. The systems provide the best performance, best sensitivity, and quality at a very competitive price. They are easy to use, reliable, andThe EZRaman-N Series provides high performance in low cost Raman instrumentation. The EZRaman-N system enables the majority of the laboratory and field Raman applications that were previously thought impossible by low cost Raman instruments. The The LabRaman Series Raman analyzers are high performance Raman systems, ideal for any academic, research, or industrial laboratories requiring a high performance Raman instrument at an affordable price. Available excitation laser wavelengths: 785nm The ProRaman-L Series Raman analyzers are high performance Raman systems suitable for industrial or laboratory experiments requiring a high sensitivity Raman instrument at an affordable price.

ProRaman-L systems feature a frequency-stabilized laser,
Pharmaceutical ApplicationDrug Discovery/Development, Final Product Testing, Formulation Analysis, Incoming Raw Material Identification,On-Line Process Control, Polymorph Identification, Quality Control, Quantification of Drug Blends, Real-time Reaction Monitoring/AnalysisDrug Discovery/Development, Final Product Testing, Formulation Analysis, Incoming Raw Material Identification,On-Line Process Control, Polymorph Identification, Quality Control, Quantification of Drug Blends, Real-time Reaction Monitoring/AnalysisDrug Discovery/Development, Final Product Testing, Formulation Analysis, Incoming Raw Material Identification,On-Line Process Control, Polymorph Identification, Quality Control, Quantification of Drug Blends, Real-time Reaction Monitoring/AnalysisDrug Discovery/Development, Final Product Testing, Formulation Analysis, Incoming Raw Material Identification,On-Line Process Control, Polymorph Identification, Quality Control, Quantification of Drug Blends, Real-time Reaction Monitoring/AnalysisDrug Discovery/Development, Final Product Testing, Formulation Analysis, Incoming Raw Material Identification,On-Line Process Control, Polymorph Identification, Quality Control, Quantification of Drug Blends, Real-time Reaction Monitoring/Analysis
Sample StateSolid, LiquidSolid, LiquidSolid, LiquidSolid, LiquidSolid, Liquid
Resolution6.5 cm-15 to 10 cm-1 (depending on model)3 to 10 cm-1 (depending on model)6 to 7 cm-1 (depending on model)5 to 10 cm-1 (depending on model)
Spectral Range100 to 2700 cm-1 (R&D Mode), 250 to 2350 cm-1 (Application Mode)100 to 4000 cm-1 (Depending on model)100 to 4000 cm-1 ( Depending on model)100 to 3300 cm-1 (Depending on model)100 to 4150 cm-1 (Depending on model)
Laser Sources785 nm785, 532 nm and NIR (Depending on model)532, 785 nm532, 785 nm785, 532 nm and NIR (Depending on model)
Regulatory Compliance21 CFR 1040.10 and 1040.1121 CFR 1040.10 and 1040.1121 CFR 1040.10 and 1040.1121 CFR 1040.10 and 1040.1121 CFR 1040.10 and 1040.11
Detector(s)TEC regulated CCDHigh Sensitivity CCD spectrograph, CCD detectorF/1.6 CCD Spectrograph, TEC cooled CCDHigh Sensitivity CCD spectrograph, CCD detectorHigh Sensitivity CCD spectrograph, CCD detector cooled to -60C
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