In time-of-flight (TOF) spectroscopy, ions are separated by their mass and are accelerated through an electric field. The velocity of the ions is used to detect the mass-to-charge ratio. Common applications of TOF spectroscopy within pharmaceutical development include metabolite profiling, surface analysis of organic and inorganic molecules, and biomarker discovery. Matrix-assisted laser desorption/ionization (MALDI) TOF spectroscopy is efficient and highly sensitive for analyzing polymeric compounds such as protein and polysaccharides. Purchasing considerations for pharmaceutical TOF equipment include the molecular stability of the compounds to be tested, requirements for instrument size, possible instrument compatibility with quantification software, and the laboratory budget.
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| Company | Shimadzu Scientific Instruments | Shimadzu Scientific Instruments | Shimadzu Scientific Instruments |
| Item | Axima Confidence MALDI TOF Mass Spectrometer | Axima Assurance MALDI Time of Flight Mass Spectrometer | Axima Performance MALDI TOF TOF Mass Spectrometer |
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| Vendor Product Page | Company Product Page | Company Product Page | Company Product Page |
| Description | An affordable, robust option for routine sample analysis performed manually or automatically, the AXIMA Confidence offers reliable mass information and MS/MS-derived structural detail. A linear mode enables outstanding levels of analysis of high- | An affordable, robust option for laboratories requiring routine manual or automated analysis of a wide variety of sample classes, the AXIMA Assurance provides high-quality, rapid MALDI mass spectra and an array of software tools for data processing | The AXIMA Performance is one of the most powerful tools in mass spectrometry, delivering information-rich spectra with greater sensitivity and higher confidence in identification. Extremely versatile, this MALDI TOF-TOF mass spectrometer utilizes |
| Type | MALDI-TOF MS | MALDI-TOF MS | MALDI CID MS/MS (TOF-TOF) |
| Pharmaceutical Application | Proteomics experiments, LC MALDI, Polymer analysis, Oligonucleotide/primer analysis | Protein profiling, Tissue imaging, Biomarker discover, Single nucleotide polymorphisms | Proteomics experiments, LC MALDI, Polymer analysis, Oligonucleotide/primer analysis |
| Sample State | Inquire | Inquire | Inquire |
| Resolution | 5000 FWHM (Linear mode); 15,000 FWHM (Reflectron mode) | up to 5000 FWHM | 5000 FWHM (Linear mode); 20,000 FWHM (Reflectron mode) |
| Ionization Method(s) | MALDI | MALDI | MALDI |
| Mass Range | 1 to 500 kDa (Linear mode) ; 1 to 80 kDa (Reflectron mode) | 1 to 500 kDa | 1 to 500 kDa |
| Scanning Speed | Inquire | Inquire | Inquire |
| Regulatory Compliance | Inquire | Inquire | Inquire |
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