In time-of-flight (TOF) spectroscopy, ions are separated by their mass and are accelerated through an electric field. The velocity of the ions is used to detect the mass-to-charge ratio. Common applications of TOF spectroscopy within pharmaceutical development include metabolite profiling, surface analysis of organic and inorganic molecules, and biomarker discovery. Matrix-assisted laser desorption/ionization (MALDI) TOF spectroscopy is efficient and highly sensitive for analyzing polymeric compounds such as protein and polysaccharides. Purchasing considerations for pharmaceutical TOF equipment include the molecular stability of the compounds to be tested, requirements for instrument size, possible instrument compatibility with quantification software, and the laboratory budget.
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| Company | LECO | LECO | LECO |
| Item | Pegasus 4D GCxGC-TOFMS | Pegasus GC-HRT High Resolution TOFMS | Pegasus High Throughput TOF-MS |
| Citations | | | |
| Price | Inquire | Inquire | Inquire |
| Vendor Product Page | Company Product Page | Company Product Page | Company Product Page |
| Description | Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometer
GCxGC, combined with the Pegasus HT TOFMS, changes the perspective of complex sample analysis. No longer limited to two analytical dimensions, the Pegasus 4D | Developed to withstand the rigor of modern analytical demands, the Pegasus GC-HRT provides high-performance MS capabilities, including acquisition speed, mass accuracy, superior relative isotopic abundance, mass resolution, and dynamic range, all | High-Throughput Gas Chromatography with Time-of-Flight Mass Spectrometer
The Pegasus® HT TOFMS system combines GC-TOFMS technology with advanced ChromaTOF®software to provide an unparalleled increase in laboratory productivity. Full-mass |
| Type | Time of Flight (TOF) | Time of Flight (TOF) | Time of Flight (TOF) |
| Pharmaceutical Application | Inquire | Inquire | Inquire |
| Sample State | Inquire | Inquire | Inquire |
| Resolution | Inquire | up to 50,000 FWHM | Inquire |
| Ionization Method(s) | Electron Ionization (EI) | Electron Ionization (EI) | Electron Ionization (EI) |
| Mass Range | Inquire | Inquire | Inquire |
| Scanning Speed | 500 Mass Spectra per sec (500 Hz) | Inquire | 500 Mass Spectra per sec (500 Hz) |
| Regulatory Compliance | Inquire | Inquire | Inquire |
| Get quote | Inquire | Inquire | Inquire |