Chromatography

Chromatography is a lab technique used to separate and identify components within a sample based on chemical or physical properties. Chromatography techniques such as gas chromatography and liquid chromatography are powerful tools for small molecule analysis in labs conducting drug impurity analysis, drug discovery, or pharmaceutical stability testing. In this hub, you can explore the latest chromatography tools and techniques available to pharmaceutical researchers, read expert advice and explore industry best practices.

Editor's Top Tech November/December 2025
With the end of 2025 approaching, we have compiled a list of this quarters top tech. read more
Understanding Drug Delivery from Spectroscopic Insights
This article explores drug delivery routes in the human body and highlights advanced spectroscopic methods - such as Raman, infrared, fluorescence, and nonlinear techniques - for investigating delivery mechanisms. It emphasizes their industrial relevance and presents an outlook on how these tools can accelerate drug development and precision in ... read more
Recombinant Lysate Manufacture: Considerations for Contamination Control
Pyrogens in general (including lipoteichoic acids, CpG DNA, viruses, and flagellin), and Gram-negative bacteria that release endotoxin, present a risk for pharmaceutical products that are administered in ways that bypass the body’s natural defenses, especially those that are infused into the bloodstream. This concern exists since endotoxin ... read more

Oral Drug Absorption - An Understanding of Lymphatic versus Portal Transport and Food Effect
Oral drugs face major challenges like poor solubility, low permeability, and enzymatic degradation, which limit their effectiveness. This article explores cutting-edge strategies to enhance drug absorption through the lymphatic system, including lipid nanoparticles, lipid prodrugs, and food-based approaches. Learn how these ... read more
Whitepaper: Disinfectant Efficacy in cGMP-Compliant Pharmaceutical Manufacturing Settings
The FDA’s intensified onsite inspections of drug production post-pandemic have underscored the importance of robust cleaning- and disinfectant-validation programs. This whitepaper focuses on the importance of disinfectant validations based on real-world conditions to maintain cGMP compliance. It discusses the current lack of ... read more
Nanoparticle Technologies: Enablers for Ocular Drug Delivery
As we continue to discover new and innovative small molecules and therapeutic compounds, over 80% of those candidates in drug pipeline are challenging to development due to their poor solubility and bioavailability. There are several ocular barriers such as tear film, corneal, conjunctival and blood barriers that cause the ... read more
eBook: Proven Applications Using Variable Pathlength Spectroscopy
This eBook provides details and insight into using Slope Spectroscopy and the CTech™ SoloVPE® variable pathlength spectroscopy system. The SoloVPE® system provides a rapid, robust, and repeatable, non-disruptive concentration measurement method for proteins, plasmid DNA, and nucleic acid modalities. Articles in this eBook ... read more
eBook: Raman Imaging in Pharmaceutical Research
In order to ensure the efficacy and safety of pharmaceutical formulations, their chemical composition needs to be monitored during the entire development and production process. read more