Formulation Development

Pharmaceutical formulation development is the critical step which links the discovery of a novel drug to commercialization. During this step, formulation scientists will determine the best drug delivery vehicle and dosage form needed to deliver a therapeutic effect based on bioavailability or other factors. Below you can explore articles, industry trends, and curated products which can help increase formulation development efficiency.

The Asymmetry Advantage: Why Early Chiral Strategy Determines API Success
Chromatography has an important role, but relying on it too long may cost of goods, extend timelines, and complicate regulatory submissions. read more
Lyophilization and Next-Generation Therapeutics: The Challenges of Scaling Up
Lypophilization helps stabilize fragile new modalities, including messenger RNA and the advanced formulation vehicles that deliver them. read more
Rethinking ADC Payloads From Cytotoxics to Targeted Small Molecules
Many patients abandon ADC therapies due to the associated toxicities. The next major leap requires designing targeted small molecules for conjugation. read more
The Use of Mycoplasma Reference Standards in the Light of the Revised Ph. Eur. 2.6.7
On 1 April this year, the Ph. Eur. Chapter 2.6.7, in its thoroughly revised form, came into force. It applies to medicinal products derived from or manufactured using living cells or biological systems and that have a realistic risk of contamination by Mollicutes (including the genus Mycoplasma). read more
Comparative Evaluation of the Efficacy of Glycopyrronium Versus Tiotropium as an Adjunct to Formoterol Therapy in COPD: A Questionnaire-Based Investigation at a Tertiary Care Facility
GFF treatment led to a significant improvement in FEV1% and FEV1/FVC ratios and resulted in faster, more consistent improvements than TFF. read more
Design, Synthesis, Characterization, and ADME Study of Novel 1,2,4-Triazole Derivatives as Anti-Tubercular Agents
In vitro anti-tubercular activity of the two novel 1,2,4-triazole derivatives demonstrated dose-dependent inhibition of Mycobacterium tuberculosis. read more

Extractables and Leachables Research is Gaining Maturity
The pharmaceutical and medtech industries, along with their associated regulators, are paying increasing attention to testing requirements for extractables and leachables (E&L) to guarantee the safety, quality and efficacy of their products. read more
Objectionable Microorganisms: Keeping Bad Bugs Out of Good Products
No pharmaceutical company wants to sell a non-sterile drug contaminated with objectionable microorganisms, but how does a company know which organisms are objectionable and how do they ensure their drugs do not contain them? read more
Automated Morphological Imaging: Deeper Insight into your Pharmaceutical Formulation or Product
Fully-automated morphological imaging of a pharmaceutical formulation or product can deliver particle size and shape information in a single measurement, and with minimal user intervention. read more
Manufacturing of Highly Potent APIs with Best-Practice Safety and Containment Control Procedures
It is a key regulatory and safety requirement that prospective hazards associated during the handling of HPAPIs are identified and understood to enable the development of Occupational Exposure Limits (OEL). read more
Parenteral Drug Packaging: Selecting the Ideal Solution for Drug Discovery through Delivery
For pharmaceutical and biotech drug developers, increased drug complexity and stricter requirements are pushing companies to find new and innovative ways to package their drug products. read more

Recent Advances in Crystalline Polymorphism Research in Drug Development
This webinar explores recent advancements in crystal screening and characterization for pharmaceutical development. read more
Speed Meets Precision: Fast Raw Material ID & Advanced Peptide Characterization
As the demand for therapeutic synthetic peptides—such as GLP-1 receptor agonists—continues to surge, biopharmaceutical manufacturers are under increasing pressure to scale production efficiently while maintaining rigorous quality standards. This ... read more
Building Agile Aseptic Operations with Skilled Teams and Smart Tech
The biopharma world is evolving rapidly, driven by rising demand for biologics and advanced therapeutics. To stay ahead, companies are adopting smart technologies and empowering teams to embrace new production methods while meeting strict regulatory ... read more