Hybrid Pharmaceutical Vials for Lyophilized Biological Drugs and Vaccines

 Most parenteral therapeutic drugs are formulated liquids that are ready to be injected or infused directly into a patient’s tissue. Typical formulations contain the active pharmaceutical drug substance, water and a host of other inactive ingredients called excipients that stabilize and preserve the drug’s therapeutic benefits. Biologic drug substance complexity has steadily increased over the years, which are more challenging to preserve and stabilize in liquid formulations. Refrigeration or even frozen storage may not be a viable nor practical option. If the drug stability in a liquid formulation cannot achieve basic regulatory storage requirements, then freeze drying (i.e., lyophilization) may be the next best option. Many vaccines are freeze-dried for improved shelf stability, particularly when refrigeration is unavailable as in third world countries. 

Download the Document

    * denotes a required field

    Please fill out the information below. If you are already registered, and this information will be filled out for you.

  • Please enter your first and last name.

  • Please enter the name of the company or institution you work at.

  • Please enter your mailing address.

  • Please enter the e-mail address you would like to be contacted at.

  • Please enter the phone number you would like to be contacted at.

    • By submitting this form, you consent to American Pharmaceutical Review storing your email address and contact information and transmitting your contact information to the content sponsor. You may request to be removed at any time.