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Orally disintegrating tablets (ODTs) represent a breakthrough in pharmaceutical delivery, offering rapid dissolution in the mouth within 30 seconds and providing significant advantages for patient compliance, stability, and ease of administration. This whitepaper from Ascendia Pharma explores the critical excipients that make ODT formulations successful, comparing performance characteristics across leading commercial platforms including Ludiflash®, PEARLITOL® Flash, Prosolv® ODT G2, and others. Discover how co-processed excipients achieve the delicate balance between tablet hardness, disintegration time, and drug loading—and learn why proper storage and packaging are essential for maintaining ODT stability. Whether you're formulating new chemical entities or optimizing existing oral dosage forms, this guide provides valuable insights into ODT technology and practical considerations for successful product development.