A versatile analytical approach to cleaning validation for multiple-linker payload ADC platforms

[Article Title]

Antibody-drug conjugates (ADCs) carry highly potent payloads, so even tiny traces left on shared equipment can put operator safety and product quality at risk. This white paper shows how Samsung Biologics built a sensitive, flexible analytical approach to cleaning validation that can detect leftover linker-payload residues at extremely low levels. It walks through two case studies. The first is a highly sensitive LC-MS/MS method for an exatecan-derivative payload. The second is a faster way to develop methods for related payloads across multiple programs. Read how these approaches support safer equipment reuse and stronger compliance, and help multi-product ADC facilities move faster.

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