American Pharmaceutical News In Review

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June 01, 2017

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Poster on Solubility Enhancement of Drugs: Polyvinyl Alcohol as Excipient in Hot Melt Extrusion Process

Limited API solubility is a challenge for most of the current drugs in the pipeline and also in the market resulting in lower bioavailability performance. One possibility to overcome this challenge is hot melt extrusion (HME), a technology where the API is dispersed into a polymer matrix.

This poster explores pharmaceutical-grade PVA as a thermoplastic and thermostable polymer for HME achieving significantly improved solubility of the API, high drug loading up to 50% and excellent thermostability during the HME processing, as well as higher stability of the extrudate at accelerated conditions.

	Industry News

Eisai, Broad Institute Enter into Research Agreement to Develop Antimalarial Medicine

FDA Approves First Generic Strattera for ADHD

Bayer Receives FDA Approval of myBETAapp and BETACONNECT Navigator

Array BioPharma, Ono Pharmaceutical Announce Partnership for Binimetinib and Encorafenib

Robert A. Ingram Named Chairman of BioCryst Pharmaceuticals

Eli Lilly Announces Phase 3 RANGE Urothelial Cancer Trial of Cyramza Met Primary Endpoint

	Featured Articles

Defining the ‘Dose’ for Dry Powder Inhalers: The Challenge of Correlating In-Vitro Dose Delivery Results with Clinical Efficacy Defining the ‘Dose’ for Dry Powder Inhalers: The Challenge of Correlating In-Vitro* Dose Delivery Results with Clinical Efficacy* The lung is an established route for the delivery of drugs to patients with a wide range of inhaled ... read more »

Dead Zone: Are Your Biological Products Ready for FDA’s Regulatory Transition? Dead Zone: Are Your Biological Products Ready for FDA’s Regulatory Transition? On March 23, 2020, hundreds of approved and pending applications for biological products will face a... read more »

	Featured Video

Webinar: Good Manufacturing Practices for Aseptic Filling of Biopharmaceuticals
Webinar: Good Manufacturing Practices for Aseptic Filling of Biopharmaceuticals
Sterilization is a critical process that packaging components undergo when processed via aseptic conditions. There are various sterilization processes... read more »

Webinar: Use of TOC Analysis for Cleaning Validation and Faster Turnaround of Production Equipment
Webinar: Use of TOC Analysis for Cleaning Validation and Faster Turnaround of Production Equipment
This webinar will discuss the process and benefits of implementing Total Organic Carbon (TOC) in place of HPLC for cleaning validation through the ... read more »

	Featured Products

Crodasol HS HP
read more »

	Featured Whitepaper

Risk Assessment for Single-Use Pharmaceutical Manufacturing Systems
Risk Assessment for Single-Use Pharmaceutical Manufacturing Systems
Single-use manufacturing systems offer numerous benefits to pharmaceutical manufacturers. But the adoption of single-use systems adds another layer of complexity to risk assessment. This white paper ... read more »

Single-Use Powder Transfer for Biopharm Manufacturing
Single-Use Powder Transfer for Biopharm Manufacturing
ILC Dover’s EZ BioPac® system was designed specifically for powder handling in the biopharmaceutical industry. EZ BioPac® vessels feature a large-diameter, open-funnel top for easier and quicker ... read more »

	Events

Webinar: Harnessing Emerging Technologies to Obtain the Best Chemical Information from Pharmaceutical Products
Webinar – 06/08/2017
Webinar: Harnessing Emerging Technologies to Obtain the Best Chemical Information from Pharmaceutical Products event details »

BIO International Convention
San Diego Convention Center – 06/19/2017
There’s no better place to connect with biotech’s top people and most innovative technologies than at BIO 2017. The ideas shared here go beyond ... event details »

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