Tangential flow filtration (TFF) is a commonly practiced technique for downstream processing applications in the biopharmaceutical industry. While traditional TFF requires multiple passes through a system, single-pass TFF runs at constant operating conditions throughout the process. This simplifies the required hardware, allows higher concentration factors and higher product recovery without significant dilution, and reduces the risk of product damage. Single-pass TFF is also a continuous process that can be run with another step. In this application note, learn more about the principles and applications for single-pass TFF.
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