Advances in upstream processing of monoclonal antibodies have resulted in higher bioreactor titers. This in turn has shifted the production burden to downstream processing, leading many to adopt a multi-column chromatography workflow for more efficient processing. Download this application note to read how multi-column chromatography compares to batch (single column) chromatography in terms of efficiency and capacity. The Protein A mAb capture process is modeled in order to explore the relationship between operating binding capacity (g mAb/L sorbent), residence-time, productivity (g/L/Hr), and the total number of columns required for optimal operation across a range of feed titers (2 g/L, 5 g/L, and 9 g/L).

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Optimizing Capacity and Efficiency with Multi-Column Chromatography

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