Analyses of Antibody Drugs Using Inert Ultra High Performance Liquid Chromatography

This article introduces analyses of monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) for quality control using an inert UHPLC system that is extremely resistant to mobile phases containing high salt concentrations. By suppressing the interaction between antibody drugs and stationary phase, the system delivered highly reproducible data. In addition, results show highly stable data, even when using a mobile phase containing high concentrations of corrosive salts.

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