Inhaled Nitric Oxide from EmphyCorp is currently being tested in clinical trials as a potential treatment for patients infected with the Coronavirus. EmphyCorp's Rx N115 Non-Steroidal Nasal Spray with no known side effects increases nasal "Nitric Oxide" which is used naturally to kill invading Bacteria, Fungi, and Viruses in the lungs, and has the potential of reducing the rate and spread of the Coronavirus among healthy individuals.
Nasal nitric oxide is a natural defence against disease. Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus. This would indicate that the use of EmphyCorp's Rx N115 Nasal Spray by healthy individuals including children and pregnant women that are currently not infected with Coronavirus and without underlying health conditions, could reduce the rate and spread of infection. N115's ability to increase nitric oxide in Patients is currently not a cure or treatment for viral infections, but rather a preventative measure to reduce the rate of infections. Clinical trials would be needed to establish the ability of N115 to cure or treat infected individuals.
The upper and lower airways form one contiguous and functionally related organ that is critical to normal lung functions. The nasal cavity produces 900-1,100 parts per billion of nitric oxide, which is used to kill invading bacteria, fungi, and viruses compared to the lungs which produce 4-48 parts per billion nitric oxide.
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Nasal nitric oxide also produces clinically useful bronchodilation and has been shown to reduce pulmonary fibrosis. Blockage of nasal nitric oxide by inflammation reduces the amount of nitric oxide reaching the lungs, which reduces critical lung functions, leading to increased lung and nasal infections, a reduced SaO2 level, reduced FEV-1 levels also leading to mouth breathing and coughing.
Nasal steroids and other OTC nasal treatments shut down the synthesis of nasal nitric oxide, which then leads to decreased lung functions and a 34% increase in infections.
In 10 human clinical trials, the inhalation of EmphyCorp Rx N115 Nasal Spray decreased nasal inflammation and increased all lung functions including increasing the synthesis of nasal nitric oxide.
EmphyCorp's U.S. Phase III Clinical Trials using N115 in Idiopathic Pulmonary Fibrosis Patients, produced statistically and clinically significant increases in FEV-1, SaO2, FVC, FEV-1/FVC ratios (52% to 86%), including Nitric Oxide, which is needed to increase bronchial dilation and fight infections.