As pharmaceutical companies move increasingly toward changing production methods from batch to continuous processing, there is a need to re-evaluate the types and formulations of the excipients used. Within a continuous process, conventional monofunctional excipients must be added through individual feeders, potentially creating multiple sources of variability. In contrast, a single high-functionality co-processed excipient requires only one feeder, thus enhancing product performance while minimizing variability. This article discusses some benefits of continuous manufacturing and reports on the evaluation of a co-processed excipient composite comprising binder-filler, lubricant, superdisintegrant and glidant, used in tablet production.
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