Pharmaceutical Raman Spectroscopy

Raman spectroscopy is a spectroscopic method utilized by pharmaceutical researchers and developers. Raman spectroscopy offers several advantages for microscopic analysis. Since it is a light scattering technique, specimens don’t need to be fixed or sectioned. Additionally, Raman spectra can be collected from a very small volume; these spectra allow the identification of species present in that volume. Water does not generally interfere with Raman spectral analysis. Thus, Raman spectroscopy is suitable for the microscopic examination of materials, cells, proteins and other biologic compounds.

In Raman imaging, the whole field of view is examined for light scattering integrated over a small range of wavenumbers or Raman shifts. Monochromatic light, e.g., a laser beam, is beamed into a sample and the substance is then analyzed for resulting molecular deformations. These molecular deformations occur in the electric field around a molecule and are referred to as inelastic scattering. Inelastic scattering is an identifying component of the Raman effect. Raman spectroscopy is versatile and can be used to analyze compounds in solid, liquid, and gaseous states.
CompanyWITec GmbHWITec GmbH
ItemRISE Microscopy Correlative Raman Imaging and Scanning Electron Microscopyapyron ∞ Imaging System
Citations
(17)
Price
DescriptionWorld's first fully-integrated Raman Imaging and Scanning Electron Microscope

RISE Microscopy is a novel correlative microscopy technique that combines SEM and confocal Raman Imaging. Through RISE Microscopy ultra-structural surface properties can be 		With the apyron imaging system you will be prepared to explore beyond the established frontiers of your field. It has been developed to overcome the boundary between ease-of-use and ultimate capability in Raman Imaging. Equipped with this seamless
Pharmaceutical ApplicationImaging of distribution of components within formulations and drug delivery systems; contaminations and foreign particulates; polymorphism and crystallinity imagingImaging of distribution of components within formulations and drug delivery systems; contaminations and foreign particulates; polymorphism and crystallinity imaging
Sample StateSolid samplesLiquid (e. g. emulsions), solid (bulk), gas (e. g. inclusions), large samples and individual sample holders possible
ResolutionSpatial : Confocal 3D Raman imaging (diffraction limited) & ultrastructural SEM imaging
Spectra l: Pixel resolution as good as 0.1 wavenumber/pixel		Spatial : Confocal 3D imaging down to 200 nm (diffraction limited)
Spectral : Pixel resolution as good as 0.1 wavenumber/pixel
Spectral RangeInquireUp to more than 9700 wavenumbers, low-wavenumber measurements down to below 10 wavenumbers
Laser SourcesUV-VIS-NIR, switching between lasers automated & software controlled, absolute laser power determinationUV-VIS-NIR, switching between lasers automated & software controlled, absolute laser power determination
Regulatory ComplianceUp to more than 9700 wavenumbers, low-wavenumber measurements down to below 10 wavenumbersInquire
Detector(s)Raman : Several different types of CCD cameras with quantum efficiencies exceeding 90%
SEM detectors: depending on SEM model		Several different types of CCD cameras with quantum efficiencies exceeding 90%
Get quote

Articles