Intravacc, has been awarded a contract with base and options that may total US$14.6 million from the US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), for the development of a prophylactic intranasal vaccine against Neisseria gonorrhoeae (NG). Gonorrhea is a sexually transmitted disease caused by the NG bacteria. Intravacc will develop a prophylactic vaccine based on its proprietary outer membrane vesicles (OMV) platform technology.
The NG vaccine, called NGoXIM, is based on gonococcal OMVs combined with sustained-release microspheres containing recombinant human IL-12, and will be administered intranasally. Proof-of-concept studies with NGoXIM have already shown the vaccine to be effective in animal models, inducing a potent, lasting, and cross-protective immune response. Intravacc will develop a complete production process for NGoXIM to generate vaccine batches under Good Manufacturing Practices. The company will work towards a non-clinical toxicity (TOX) and Clinical Trial Material batch to execute a Phase I study in healthy adults, investigating the safety of the vaccine and generating efficacy data. The IL-12 containing microspheres called GneX12 will be developed and produced by Therapyx Inc.
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