Khondrion announced the grant of key patents in the United States (US 9,388,156 B2), Europe (EP 2872497) and Hong Kong (HK 15110180.2) providing protection for its library of chromanyl-derivatives compounds, including the lead clinical-stage KH176 for the treatment of mitochondrial related disease. The grant of these patents provides the company exclusive rights for KH176 and the other compounds of the library until at least July 2033.
"We are extremely satisfied with the granting of this important asset within our IP portfolio," said Jan Smeitink, CEO of Khondrion. "The grant of these patents brings further recognition of the quality of the innovation being carried out by the Khondrion team. We are actively working on the development of our pipeline and additional level of protection of novel products is pending."
The patented invention relates to novel chromanyl derivatives compounds among others useful for treating or preventing mitochondrial disorders and diseases or conditions associated with mitochondrial dysfunction such as Parkinson's disease or adverse drug effect. The patents cover Khondrion's lead and clinical stage molecule KH176.
Khondrion's KH176 is an orally bio-available small molecule developed by Khondrion for the treatment of mitochondrial (-related) diseases. The compound is a member of a new class of Khondrion drugs essential for the control of oxidative and redox pathologies. KH176 is currently evaluated in the KHENERGY study, a single-center, double-blinded, randomized, placebo-controlled 2-way cross over Phase 2 trial in patients with MELAS, MIDD and mixed phenotypes (ClinicalTrials.gov Identifier NCT02909400). Results of the Phase 2 trial are expected Q1-2018.