REGENXBIO has completed dosing of the fourth cohort of six patients in a Phase I clinical trial evaluating RGX-314 for the treatment of wet age-related macular degeneration (wet AMD or nAMD). A total of 24 subjects have been dosed in the trial. The company also announced that an updated summary of Phase I study results, including additional study results for the first three cohorts since its previously reported interim results, are to be presented at the American Academy of Ophthalmology (AAO) 2018 Annual Meeting in Chicago, Illinois.
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"We are thrilled with our progress in the clinical development of our lead product candidate, RGX-314, and pleased to have completed dosing of subjects in the fourth cohort at a higher dose," said Stephen Yoo, M.D., Chief Medical Officer of REGENXBIO. "Wet AMD is a leading cause of irreversible blindness and visual impairment in the world. We continue to be encouraged by the positive interim data for RGX-314 and the potential of NAV AAV8 gene therapy as a one-time treatment for wet AMD."