Therapix Biosciences announced positive results in its pre-clinical study evaluating THX-210, a proprietary novel pharmaceutical preparation containing non-psychoactive cannabinoid cannabidiol (CBD) and palmitoylethanolamide (PEA). This study is consistent with Therapix's pipeline to develop cannabinoid based therapies. THX-210 is intended for the treatment of epilepsy, as well as inflammatory conditions.
The study consisted of in vitro tests which examined potential synergy between CBD and PEA. The study was performed in hepatocytes model of fat accumulation, where each compound was tested in a range of concentrations. In these tests, PEA had shown no effect of its own, while the effect of CBD was enhanced by the addition of PEA, lowering the required effective concentration of CBD. Thus, THX-210 has demonstrated superior efficacy as compared to the effect of CBD alone.
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"An area of opportunity exists in the treatment of diseases relating to epilepsy and ASD (Autism Spectrum Disorders)," said Ascher Shmulewitz, MD, PhD, Therapix's Chairman and Interim CEO. "Therapix tested its proprietary THX-210 on in vitro models designed to show its entourage potential. The synergy between the components of THX-210 as reflected in this in vitro study has the potential of reducing side-effects of high dose CBD-rich treatments."
"We are very encouraged by these test results as they point to a novel way to utilize a mechanism of action, on which THX-210 is based,” Adi Zuloff-Shani, CTO of Therapix Biosciences said. “This is the first time that PEA was shown to exert a synergy toward CBD in an in vitro model. We are encouraged to further explore this technology in the near future. Due to the unique mechanism of action of THX-210, we see several areas of potential application. THX-210's successful application could make a meaningful difference for patients."