Spring Bank Pharmaceuticals has initiated dosing patients in a Phase 1 trial of SB 11285, the company’s intravenously (IV)-administered STING (STimulator of INterferon Gene) agonist. The Phase 1 trial aims to evaluate safety, tolerability and initial anti-tumor activity of IV SB 11285 in patients with advanced solid tumors.
“Working with our principal investigators in the United States, we are thrilled to announce that we have been able to deliver SB 11285 intravenously to the first patient in our Phase I trial of advanced solid tumors,” said Atif Abbas, M.D., Vice President & Head of Oncology/Immunology Development at Spring Bank. Dr. Abbas continued, “We look forward to working with a prominent group of clinical investigators to explore the safety, tolerability and anti-tumor activity of our IV-administered STING agonist during the monotherapy and combination with a checkpoint inhibitor dose escalation phases of this Phase 1 trial. We believe the primary benefit of delivering SB 11285 by the intravenous route, as opposed to intratumorally like other STING agonist compounds currently in development, is the potential ability to treat a broader range of cancers and patients in the community oncology treatment setting.”
Subscribe to our e-Newsletters
Stay up to date with the latest news, articles, and events. Plus, get special offers
from American Pharmaceutical Review – all delivered right to your inbox! Sign up now!
SB 11285 is a novel STING agonist immunotherapeutic agent designed and developed for IV administration being investigated for the treatment of selected cancers such as certain breast cancers, lung cancers, colo-rectal cancers and melanoma. In vitro and in vivo preclinical findings indicate that SB 11285 could be used to target a variety of tumors at various anatomic sites and has the potential to enhance the activity of other therapeutic modalities such as immune checkpoint inhibitors, PARP inhibitors and other chemotherapeutics.
Part 1 of the IV SB 11285 Phase 1 trial is a dose-escalation study with monotherapy followed by combination with a checkpoint inhibitor and is designed to determine a recommended Phase 2 dose. Part 2 of the trial will explore IV SB 11285 antitumor activity in combination with a checkpoint inhibitor in selected tumor types. The trial will be conducted at multiple sites in the United States. The company hopes to be in a position to report top-line results from this Phase 1 trial in mid-2020.